Skin Science & Education 5 min read • Last Reviewed: 2026-10-20

Skin Bio-Remodelling vs. PRP vs. PRF: Comparing Cellular Skin Quality Treatments

Compare centrifuge speeds, platelet concentrations, fibrin scaffolding, and dual-weight hydration technology across PRP, PRF, and Skin Bio-Remodelling so you know how each regenerative modality works.

Written & Reviewed by: Mariam Jomaa (Dermal & Skin Clinician)

Mapp Aesthetics Clinical Team

Clinical Summary & Key Takeaways

PRP spins at ~2,900 rpm with an anticoagulant to yield 7-10ml of plasma (5x platelet concentration) ideal for full-face needling and scalp coverage.
PRF spins at ~2,000 rpm in an additive-free tube to retain a 10x concentration of platelets, white blood cells, and fibrin scaffold for under-eyes and targeted folds.
Skin Bio-Remodelling uses dual high- and low-molecular-weight hydration to stimulate collagen and elastin across the face, neck, décolletage, and hands without adding volume.

PRP vs PRF: Key Clinical Differences

Platelet rich plasma (PRP) and Platelet rich fibrin (PRF) are both treatments that use your own body’s platelets from your blood, however there are a few key differences between PRP and PRF

Platelet-Rich Plasma (PRP) Protocol

The blood is spun at higher speeds eg 2900rpm for 4 minutes in the T-lab centrifuge to separate the plasma layer which is rich in platelets
Contains a 5x concentrated volume of platelets
Platelets release growth factors quickly
Injection technique involves using a small needle 4mm long, injecting the PRP all over the face, neck and/or hair. The remaining PRP is then skin needled on top for further rejuvenation
Downtime: pink/red skin which lasts for a few hours, possible bruising, and swelling
Benefits: skin rejuvenation, reduce pigmentation by brightening the skin, improve skin texture and shrink pore size, minimise fine lines and wrinkles by stimulating collagen and elastin production, tighten the skin, hair growth, reduction of hair shedding
The blood collection vial contains an anticoagulant which is a medication that keeps the blood thin, preventing it from clotting and allowing the PRP to be injected within 40-60 minutes
The anticoagulant which creates a mild stinging sensation when PRP is injected to the face can make this procedure uncomfortable, therefore numbing cream is used prior to treatment to make it more comfortable
Volume of PRP produced is 7-10mls from 2 vials of blood collected
The entire procedure takes 45-60 minutes to complete

Platelet-Rich Fibrin (PRF) Protocol

Downtime: under eye swelling for 1-3 days, redness under the eyes or nasolabial folds, possible bruising at injection site

The entire procedure takes 30 minutes to complete

The blood is spun at lower speed eg. 2000rpm for 4 minutes in the T-lab centrifuge in order to retain the fibrin matrix which acts as a scaffold to support new cell growth
Contains a 10x higher concentration of platelets, white blood cells, stem cells and fibrin matrix
Growth factors are released slowly due to the fibrin matrix creating longer lasting results
Injection technique involves using a canula, which is a long blunt needle, injected into focus areas such as the under eyes or nasolabial folds to build volume in these areas overtime through the stimulation of skin regeneration. PRF can also be injected like PRP however less volume of PRF is produced and may require more vials to be collected
Benefits: improve under eye hollowing and darkness by building collagen under the eyes, stimulate hair growth and reduce hair shedding, soften deep lines and wrinkles, overall skin rejuvenation
the blood collection vial is empty meaning there are no preservatives in the vial, it is purely your own blood. This makes it prone to clotting, meaning the PRF needs to be injected within 15-20minutes before it is no longer viable due to clotting
The procedure is generally comfortable as a blunt needle is used. Numbing cream is not required as the pain level is very low for this procedure but it can be requested
Volume of PRF is 3-6mls from 2 vials of blood collected

Skin Bio-Remodelling: The Next Generation of Cellular Rejuvenation

If you’ve been exploring non-surgical options for rejuvenating your skin, you may have come across the term bio-remodelling. Unlike traditional cosmetic treatments, bioremodelling works with your skin’s natural biology to hydrate, remodel, and restore your skin from within.

What Is Skin Bio-Remodelling?

Bio remodelling are an innovative type of treatment designed to improve skin quality and stimulate the natural production of collagen and elastic, two essential components that give your skin structure, elasticity, and youthful bounce.

Rather than adding volume, bioremodellers work by improving the overall texture, tone, and hydration of the skin, resulting in a more youthful and radiant appearance.

High & Low Molecular Weight Formulation Science

The product we use is one of the most well-known bio-remodelling on the market. It contains one of the highest concentrations of pure (HA), a substance naturally found in our skin that helps retain moisture and plumpness.

But what sets this product apart is its unique formulation. Using a patented technology, it combines high and low molecular weight HA, allowing it to spread evenly under the skin and stimulate tissue regeneration at a cellular level.

Key Skin Quality Benefits

Intense hydration - especially for dry, crepey or mature skin

Improved firmness and elasticity

Smoother, more radiant skin

Natural-looking results with no added volume

Minimal downtime - quick and simple procedure

What Areas Can Be Treated?

This product is most commonly used on the face, but it can also rejuvenate other areas, including the:

This makes it a versatile option for clients wanting a comprehensive approach to skin ageing.

Neck
Décolletage
Hands
Arms
Abdomen

The In-Clinic Treatment Process

At Mapp Aesthetics, your journey starts with a thorough consultation to ensure it's the right fit for your skin goals.

The procedure itself involves a series of injections at specific points under the skin. Most clients require two treatments spaced 3 to 4 weeks apart, with maintenance treatments recommended every 6-12 months.

Discomfort is minimal, and side effects are usually limited to mild swelling or redness at the injection sites for 24-48 hours.

Who Is Skin Bio-Remodelling Ideal For?

The bio-remodelling is ideal for:

Men and women aged 30+
Those experiencing early signs of skin ageing
Clients wanting glow, firmness, and hydration without adding volume
Anyone seeking a more natural and regenerative approach to skin care

Bio-Remodelling vs. Structural Volumising Treatments

While volume treatments to specific areas (like cheeks or lips) restore volume. Think of it as improving the canvas of your skin itself rather than reshaping your features. It’s a complementary treatment rather than a replacement and can work beautifully alongside cosmetic treatments, PRP, or microneedling.

Personalised Skin Guidance at Mapp Aesthetics

Bioremodelling treatments are transforming the way we approach skin ageing. With natural, regenerative effects and subtle but powerful results, it’s no wonder this treatment is gaining popularity among both practitioners and clients alike.

At Mapp Aesthetics, we specialise in advanced skin rejuvenation treatments that work with your body, not against it. If you’re curious whether our products or another bioremodeller could benefit your skin, book a consultation today.

We’d love to guide you on your skin journey.

Clinical Pathways at Miranda & Warwick Farm